Phone: +33 (0)1 34 86 77 01 | email : info@excilone.com

MOLECULAR PATHOLOGY

A simple, economical and proven solution

Digital Pathology

Integrated solutions for FISH

Solutions for pathology

Molecular Pathology

Solutions for Cytogenetics

Analysis of nanoparticles

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cutting-edge technology

Laser microdissection
Automated tissue dissection

Accuva Cellect

Accuva Cellect : Laser Capture Microdissection (LCM) System

Power and precision in one instrument

Soft IR laser, ideal for capturing single cells and small numbers of cells
The UV laser offers superior speed and precision, optimal for dense tissue structures
A simple and intuitive system enables rapid microdissection that improves downstream analysis

Capture only the cells you need

Isolate only the desired cells, and enrich for specific cell types to enable a more accurate genetic profile for early-stage analysis.

Features and Benefits

Dual-laser system
Enables a wide range of applications, from single-cell isolation to large-scale biopsy extractions, increasing flexibility and helping to ensure reliable cell capture on all sample types without contamination or morphological damage.
Intuitive software
Enables rapid isolation of specific cells in five simple steps and quality control with visual inspection, facilitating sample documentation and preservation.
Service and Support
Training and 48-hour response times to get you back to work.
Flexible Sample Preparation
Support for a wide range of slide types and sample preparation formats. If you have an existing workflow, we can work with it or help validate a workflow with you.
Compact Design
The footprint is approximately 32% smaller than other microscope and laser systems on the market, saving valuable bench space.

More information about laxcoinc

MiniPunch®

This innovative tool allows users to select an area of interest from a digitized histological slide and automatically collect 200 µm diameter tissue samples from the corresponding paraffin block. This technology bridges the gap between histology and molecular analysis using artificial intelligence tools.

• Obtain molecular biology data from areas
as small as 200 µm in diameter

• Selection of areas of interest from digital slides

• Automated coring of areas of interest on paraffin blocks
(up to 16 blocks processed in a single run)

• Purification and extraction of DNA/RNA without deparaffinization

Benefits
Applications
Consumables
Workflow
Technical specifications

Compact and ergonomic system

Integrated touch screen.
Keyboard and mouse stored in a drawer at the base.

Advanced technology

Intuitive user interface: MiniPunch^®software guides you step by step through the development of your project
Automated tray with two removable supports (block and tube supports)
Execution speed: approximately 40 seconds per sample

Optimal traceability

Capture of the block ID and reading of the barcode to ensure traceability.
Image capture at every key step of the process.
Creation of an Excel tracking file.

Extended compatibility

ExciloneView^® software allows you to view and select areas of interest on scanned slides. ExciloneView^® is compatible with most slide scanners currently on the market.

Try the free version of ExciloneView^® (Digital pathology– Excilone).

Precision of tissue sampling

Ultra-precise sampling thanks to the automatic overlay of virtual slide annotations on the block image.
Precise and reproducible definition of the core point.

Large capacity

Up to 16 paraffin blocks/tray.
A support for a 96-well plate or for a rack of microtube strips.
Needle rack (96 needles/rack).

Sample Preservation

RNase and DNase free single-use needles for molecular analyses.
Small samples are taken to preserve paraffin blocks.

The MiniPunch® is ideal for various applications in Oncology, Neurology, Immunology, Immuno-oncology, Infectiology and any other fields where molecular analysis (nucleic acid and protein) needs to be linked to an area of interest in FFPE tissue.

Our R&D laboratory has verified the compatibility and feasibility of numerous analyses on these micro-samples, such as :

Mutation research by qPCR, dPCR and NGS (with sequence capture probe)
Gene expression level analysis by qRT-PCR, RT-dPCR and RNAseq

Excilone has also developed a proprietary technique for extracting nucleic acids without a deparaffinization step from FFPE micro-samples in order to carry out molecular analyses.

Contact us for more information.

Needle plate^* 200µm in diameter (96 units/plate)

^*RNase & DNase free

REF : MiP-P96200

* Optional steps: only when the process is performed with scanned slides.

CE marking : Built to CE/CEM requirements and certified to these standards.

Components	Description
Dimensions	Width : 560 mm Depth : 720 mm Height : 650 mm
Weight	Approximately 45 kg
Alimentation	85/264 VAC, 0.8A à 230 VAC, 47/63 Hz
Number of blocks	Up to 16 per tray
Needle	200 µm diameter – 96 units/rack
Collector tube format	96-well microplate 0.1 or 0.2 ml strips or microtubes (0.5 ml coming soon)
Work surface on the block	40 mm x 28 mm
Max. paraffin thickness	10 mm
Length of carrots	Configurable
Coring area	Manual determination on the block image
Speed	Approximately 40 seconds per sample

Indicative but non-contractual specifications.

Request more information