Innovative range of integrated systems for pathology
Solutions
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Minicore®3
MiniCore®3 includes an 8-position carousel as standard, allowing you to use up to 7 donor blocks simultaneously, saving you even more time and effort.
Core zone selection in donor blocks is performed by zone drawing or pointing, directly on screen on the donor block image superimposed on that of the H&E control blade.
The MiniCore®3 Control Station software interface displays all information in real time. In the event of difficulties on a donor block, the user can easily switch blocks and continue his tissue array, without any loss of quality.
Minicore®4
The MiniCore®4 Automatic Tissue Arrayer is designed to make the construction of high-density tissue arrays simple, fast and precise.
MiniCore®4 includes a 20-position tray that allows the user to build up to 4 receiver blocks and arrange up to 16 donor blocks per run.
Minicore® offers a complete range of needles from 0.6 mm to 2 mm.
The system is equipped with an on-board PC with touch screen.
The MiniCore®4 software interface displays all information in real time. Coring zones in donor blocks are selected directly on-screen from the donor block image, automatically superimposed by artificial intelligence on the image of the H&E control blade.
Easy TMA Creator
With our TMA construction software, you can design any type of format from a list of Excel® specimen identifiers.
During construction, MiniCore® 3 automatically uses your tissue array configuration file. Position errors are virtually eliminated.
Whenever a donor block is required, its ID is displayed on the screen. Specimen errors are greatly reduced.
Finally, each step is recorded in a log file to guarantee perfect traceability.
Core drilling needle sets additional
SpotBrowser® 4Spot identification is undoubtedly the most time-consuming and difficult stage in preparing tissue array spots for analysis. Identification includes detecting spots on the slide scan, then associating each of these spots with their respective position in the initial plan of your Arrays tissue, to create the essential traceability link between spot and patient data.
Spot Browser® 4 includes a de-Arraying tool for data detection and association. Simply import your tissue array map file, and Spot Browser® 4 takes care of the rest. Interactions and corrections are always possible in cases where the Tissue Array is truly in poor condition on the blade (severe deformations).
In many cases, spots are “scored” visually, because the pathologist’s expert eye can not so easily be replaced by software, however powerful.
To meet this need, Spot Browser® 4 allows users to create their own data fields in various formats (free, numeric, drop-down list…) to enter their annotations. The user can quickly navigate from one spot to another and enter annotations.
Input and imported data can be exported in Excel format for statistical processing.
For analysis of large numbers of spots or for quantitative analysis, Spot Browser® 4 offers a comprehensive tool for automatic image analysis.
HSV color and morphometry are the characteristics used. Each of these features can be used alone or in combination, depending on the objects to be detected.
Users can easily create their own detection protocols, with one or more types of object to be detected, and with or without nesting, for example, to count labeled nuclei in a tumor zone. Cytoplasmic and membrane labelling can also be detected.
Detection and analysis protocols can be saved in internal libraries for future use.
The user can analyze spots one by one or in automatic batch mode, and analyses can combine human intervention (zone tracing, for example) with fully automatic modes.
Raw and interpreted results can be exported to Excel.
SnapFrost®
SnapFrost® guarantees ultra-fast, reproducible freezing of your samples.The reference technique using Iso pentane refrigerated down to -80°C, which unlike liquid nitrogen does not degas, enables rapid, reproducible temperature transmission to the sample.
Molecular content does not diffuse into the sample, cell membranes are preserved and tissue damage is avoided.
Ergonomic and flexible in use, SnapFrost® features two individually controllable freezing chambers to suit all freezing protocols and tissue types. The volume of the lower chamber containing Iso pentane can be modulated (from 5 to 680 ml) to suit all sample sizes.
Alternative solutions such as the Novec 7100 can also be used in the SnapFrost®, retaining the advantages of the appliance and guaranteeing high quality freezing.
Programmable, compact and autonomous, SnapFrost® can be moved to different freezing zones, guaranteeing flexibility, time savings, safety, quality and reproducibility in your freezing operations.
Process Record SlidesTraditional tissue controls have long been the norm in immunohistochemistry but they have limitations: lack of standardization, variability from one batch to another, and risk of misuse. PRS slides revolutionize immunohistochemistry by replacing these tissue controls.
Standardizing the IHC staining process using the PRS tool offers several advantages in antibody validation:
Quantitative assessment: The predetermined quantification of the surrogate antigens enables quantitative assessment of the intensity of the staining, thus facilitating the objective assessment of the performance of the antibodies used.
Quality control: The PRS tool serves as a quality control measure, allowing users to verify the reliability and consistency of antibody staining between different batches and experiments.
Error detection: Deviations between the observed staining pattern and the expected result based on the PRS tool indicate potential errors in antibody selection or application, prompting further investigation and corrective action.
Workflow efficiency: Standardization of the staining process streamlines workflow procedures, reduces variability, and optimizes laboratory efficiency in IHC testing; there is more control tissue pattern to be deposited on the slide in addition to the tissue to be tested
PRS eliminates false negative/positive staining results through 100% slide control; each IHC slide is assessed individually.
PRS makes it possible to do away with expensive off-the-shelf control blocks.
PRS ensures accurate and consistent results while complying with ISO 15189 standards. Primary and secondary protein targets with certified antigen expression levels are recognized as an ISO 13485 medical device. PRS helps in achieving accreditation and regulatory compliance with ISO15189, CLIA and ACP standards.
