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Automation solution for scanning and analysis of tissue-based FISH slides

PRODUCTS for fish

slide preparation, digitization and analysis


EasyFish® complements Excilone’s comprehensive Fish solution, which already includes Cytotest® probes, the CytoHyb500 denaturation-hybridization system and PathScan® scanners. Efficiency, openness, practicality and user protection.

EasyFish® is a device that enables complete automation of the Fish slide pretreatment process.
(tissue sections) with :

Efficiency and openingspan
• Total automation of the process (dewaxing, rehydration, permeabilization, enzymatic digestion, dehydration) with intermediate washes
• Extemporaneous enzyme preparation (automatic dilution from concentrated solution)
• Heating the slides at the start of the protocol
• Protocol standardization
• Suitable for all probes, regardless of supplier

• Ready-to-use reagents (except enzyme)
• Ready-to-use enzyme dilution buffer for automatic extemporaneous preparation
• Management of 1 to 20 slides per run, with adaptation of the reagent volume used
• Management of multiple digestion times in a single run using semi-automatic mode
• Pre-recorded default programs
• Customizable programs
• French-language software interface with touch-screen control panel
• Monitoring of technique progress, with indication of time remaining in the current step and total time.

Operator safety and protection
• Reduce reagent handling by using ready-to-use solutions
• Use of substitutes for the dewaxing step
• “Autoboot” of the appliance on start-up with check of correct operation
• Self-cleaning of all manifolds on ignition and at the end of the process
• Control of reagent volumes drawn from and dispensed into the reaction chamber, with alarm in case of insufficient volume
• Waste volume control with fill alarm
• Presence control of waste, alcohol and distilled water containers with alarm

Dimensions and electrical features
• Floor-standing machine with adjustable feet and castors.
• Dimensions: 700 x 500 x 1000 mm (W x D x H)
• Weight: 50 kg
• Voltage: 220-240 V
• Power: 1500 W

Reagents not supplied
• Distilled water (800 to 1000 ml for a cycle of 20 slides)
• Absolute alcohol (300 to 500 ml per cycle of 20 slides)

Cytotest FISH probes

Cytotest specializes in the design and production of probes for fluorescence in situ hybridization of DNA (FISH). FISH is a powerful technique designed to detect the presence or absence, location, integrity and quantity of genomic sequences in tissue or cell samples. Introduced in the early 1980s as a cytogenetic research tool, FISH is today the most important technique for the clinical diagnosis of chromosomal abnormalities.

Since its creation, the company has advanced its fluorescently-labeled nucleotide production techniques from the design to the manufacture of FISH probes. To date, Cytotest has developed and successfully tested a highly diversified range of FISH DNA probes for molecular diagnostic applications in oncology, personalized medicine, prenatal testing, oncology and other fields.

The Cytotest range includes probes for both clinical and research targets, as well as customized products (custom probes). New products are constantly being added, partly thanks to our in-house R&D efforts, but more often as a result of requests from our customers to develop specific tests, particularly for rare cancers and companion diagnostics.











All products are manufactured in compliance with current regulations, and undergo quality testing to ensure they meet the most stringent standards. Regular optimization efforts have resulted in products of excellence. At the same time, Cytotest keeps a close eye on scientific and technological advances, observes cutting-edge discussions on diagnostic industry standards, certification and regulatory requirements, and remains attentive to changes in consensus concerning in vitro diagnostics and laboratory testing.

With a multi-disciplinary team of passionate and dedicated researchers, Cytotest can perform manufacturing at any scale and is able to offer solutions for a wide range of diagnostic test needs, from standard probe production to flexible custom design. Cytotest scientists have strategic collaborations to develop molecular diagnostic tests for new and rare pathologies, uncovered diagnostic niches and for commercialization in underserved regions of the world.

The mission of CytoTest Inc. is to transform human genomic discoveries into useful products, and to design, manufacture and validate genetic and clinical diagnostic reagents of the highest quality. Their main objective is to develop state-of-the-art, yet affordable, molecular cytogenetic solutions. Cytotest is dedicated to providing cost-effective products, proactive customer service and reliable technical support.


Get a quote

Request a quote for the Cytotest product range


The CytoHYB CT500 denaturation and hybridization instrument is a programmable system for automated processing of FISH protocols on samples deposited on glass slides.

The machine offers a number of advantages, including convenient touch-screen programming, an integrated USB port, unrivalled heating speed and precision, minimal temperature variation and a higher humidity range. A unique design with liquid gutters provides convenient humidification and stable humidity control inside the chamber. The instrument is easy to clean, and there’s no need to use disposable foam strips for humidity, or any other consumables to replace.

Accepting a wide range of sample types, the tray is equipped with sliding guides that hold the slides in place and allow one-handed placement and removal. Its use considerably reduces working time without compromising precision and reproducibility.

The product is suitable for a wide variety of experimental denaturation and hybridization strategies, with four distinct modes of operation: denaturation/hybridization, hybridization, customization and PC processes.

R in situ. The integrated hot-water tank and sealed heating cover ensure perfect experimental reproducibility, for processing up to 12 slides simultaneously.

Available for 110-120V or 220-240V power supply.

PathScan® Combi

PathScan® Combi is an automated platform for brightfield slide scanning and analysis on tissue, and for whole-slide Fluorescence scanning in up to 6 colors.

PathScan® Combi is a histological slide scanner that combines transmitted light and fluorescence scanning thanks to a dual-camera system (color and monochrome):

  • Oil immersion scanning of tissue FISH slides
  • Whole slide immunofluorescence scanning (up to 5 colors)
  • Brightfield scanning, including immersion (high-resolution)

PathScan® Combi enables brightfield and fluorescence images to be matched for FISH analysis using EVA® software, in the same tumor zone as that previously identified by the pathologist in brightfield.

With its dedicated Web application, PathScan® Combi provides remote access to acquired images and password-protected access to individual files and working environments.

Specifications :

  • Available lenses: 2x, 4x, 10x 20x, 40x, 60x immersion (upgradeable configuration).
  • Capacity: 8 blades
  • Number of lenses : Up to 7
  • Resolution at x20: 0.5 micron/pixel, 0.25 µm/pxl at x40, 0.107 µm/pxl at x60 (immersion)
  • Image compression: JPEG-2000
  • Bar code reader: Yes
  • Filters: DAPI, FITC, TRITC (scalable configuration)
  • Filters: up to 5 positions (upgradeable configuration)
  • Backlight illumination: LED
  • Illumination Fluorescence: Metal-halide
  • Display: 24” LCD screen (1920X1200)

The scanner complies with the In Vitro Diagnostic Regulation (IVDR) (EU) 2017/746.

Excilone® View Web

Excilone® View Web is a powerful web-based platform for managing, viewing and sharing virtual slides from Excilone PathScan® Combi and PathScan® Touch slide scanners, as well as from the market’s leading slide scanners.

Allows you to centralize all your virtual blades in the same environment, regardless of image format.

Excilone® View Web can be installed on physical servers or in the cloud, and an SSL certificate with Https protocol ensures a secure connection and data protection.

The Excilone® View Web license is perpetual with no limit on the number of users.

Excilone® View Web is available in English and French. The platform is accessible from PCs, Macs and tablets. And it’s browser-compatible.

Excilone® View Web allows you to perform the following operations:

  • Access virtual blades from your web browser, without installing any software, and from anywhere.
  • Navigate any type of virtual slide: brightfield, fluorescence and any format.
  • View multiple slides simultaneously.
  • Synchronize blade display.
  • Manage blades within studies according to your different projects.
  • Give your collaborators or partners access to your studies by managing their access rights (management, annotation or consultation rights).
  • Invite other users to join you in meeting mode for a virtual multi-headed slide show.
  • Annotate and measure virtual slides.

Key words :

  • Blade visualization with simple web access.
  • Access with a password-protected user ID.
  • Manage users and their associated rights within studies.
  • Image management by study and sub-study.
  • Link documents to your studies.
  • Share your studies by inviting other users.
  • Maintain traceability with the audit function.
  • View slides in brightfield and fluorescence.
  • Multi-channel display and Z-stack navigation.
  • Compatible with almost all image formats.
  • Synchronized serial blade navigation.
  • Annotations and measurements (import/export).
  • Meeting mode for virtual multi-head playback.
  • Collaborative solution for teaching and research.
  • Perpetual license and unlimited number of users.
  • Numerous virtual blade formats.
  • Local and Cloud servers.

Compatible image formats :

  • Leica® (TIF, SVS, AFI)
  • PathScan® (TIF, GXP)
  • PathScan® Touch (TIF, SVS)
  • Hamamatsu® (NDPI, NDPIS)
  • Huron® (TIF)
  • 3DHistech® (MRXS)
  • Olympus® (VSI)
  • Zeiss (CZI)

Excilone® View Analyse

Excilone® View Analyse (EVA®) is digital pathology software for viewing images from Excilone PathScan® slide scanners and other leading slide scanners.

EVA® offers advanced features for intuitive navigation of all your slides (brightfield, fluorescence).

With Excilone® View Analyse you can also :

  • View several virtual slides simultaneously
  • Annotate slides and share images
  • PathScan® FISH slide analysis

The benefits:

  • Independent analysis of probe suppliers ;
  • Core segmentation using artificial intelligence ;
  • Core gallery for easy interpretation ;
  • Dynamic link between image and core gallery results ;
  • Tools to facilitate review and correction of results (addition, deletion of cores).

For research only