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Digital Pathology

Acute Large Cell Lymphoma - ALL


Réf. : 18-001


Two Color, Two Fusion Translocation Probe

Ref: 18-001

The IGH/BCL2 DNA-FISH Probe is designed to detect the translocation between the IGH gene located on 14q32 and the BCL2 gene located on 18q21, using fluorescence in situ hybridization (FISH).  The translocation between the IGH and BCL2 gene is designated as t(14;18)(q32;q21) and is the hallmark of follicular lymphoma (FL).  The t(14;18) translocation is more frequent in lower FL grades, such as FL grades 1 and 2 (88%), than in higher grades, such as FL 3b (4-13%).The translocation is also detected in 30% of diffuse large B-cell lymphoma (DLBCL) cases, but is less frequently detected in other non-Hodgkin lymphomas. By conventional cytogenetics, the t(14;18)(q32;q21) translocation that involves the IGH and BCL2 genes is indistinguishable from the t(14;18)(q32;q21) translocation that involves the IGH and MALT1 genes.  Such translocations can be distinguished by using the respective DNA-FISH probes.